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Clinical and Diagnostic Laboratory Immunology, Jan 1997, 104-106, Vol 4, No. 1
Copyright © 1997 by the American Society for Microbiology. All rights reserved.

Antibody production against hepatitis C virus core and nonstructural 3 proteins is highly sensitive to deficits in T-cell function

Y Ando, A Sonnerborg, L Barkholt, A Birkett, BG Ericzon and M Sallberg
Division of Clinical Virology, Huddinge University Hospital, Karolinska Institute, Sweden.

The influence of suppression of CD4+ and CD8+ T cells on the humoral responses to hepatitis C virus (HCV) core and nonstructural 3 proteins was studied. An increasing viral burden cannot substitute for the lack of functional T cells in maintaining humoral HCV-specific responses.




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