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Clinical and Diagnostic Laboratory Immunology, 11 1997, 774-777, Vol 4, No. 6
Copyright © 1997 by the American Society for Microbiology. All rights reserved.

Salmonella infection increases porcine antibacterial peptide concentrations in serum

G Zhang, CR Ross, SS Dritz, JC Nietfeld and F Blecha
Department of Anatomy and Physiology, Kansas State University, Manhattan 66506, USA.

PR-39 is a multifunctional neutrophil peptide involved in host defense and inflammation. To investigate the involvement of PR-39 in a Salmonella choleraesuis infection, a PR-39 enzyme immunoassay was developed. The concentrations of PR-39 in serum were 13.6 +/- 1.9 ng/ml before challenge and increased (P < 0.01) threefold by 10 to 14 days postinfection. Peripheral blood neutrophil counts paralleled the changes in the concentrations of PR-39 in serum, both returned to basal values by 4 weeks postinfection. These findings suggest that the concentrations of serum PR-39 reflect the involvement of this antibacterial peptide in the host's response to an S. choleraesuis infection.


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