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Clinical and Diagnostic Laboratory Immunology, March 1998, p. 254-255, Vol. 5, No. 2
1071-412X/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Use of trans-Sialidase Inhibition Assay in a Population Serologically Negative for Trypanosoma cruzi but at a High Risk of Infection

María S. Leguizamón,2 Graciela Russomando,1 Antonieta Rojas de Arias,1 Margarita Samudio,1 Margarita Cabral,1 Stella Maris González-Cappa,2 Alberto Carlos C. Frasch,3 and Oscar Campetella3,*

Instituto de Investigaciones en Ciencias de la Salud, Universidad Nacional de Asunción, Asunción, Paraguay,1 and Departamento de Microbiología, Facultad de Medicina, Universidad de Buenos Aires,2 and Instituto de Investigaciones Biotecnológicas, Universidad Nacional de Gral. San Martín,3 Buenos Aires, Argentina

Received 8 September 1997/Returned for modification 6 October 1997/Accepted 23 December 1997

trans-Sialidase inhibition assay (TIA) was employed in a population at high risk of Trypanosoma cruzi infection. From 20 serum samples that were negative by conventional serologic and parasitologic assays, 18 (90%) were reactive in TIA, providing further evidence of the higher sensitivity of TIA and suggesting that the actual prevalence of T. cruzi infection might be underestimated.

* Corresponding author. Mailing address: Instituto de Investigaciones Biotecnológicas, Universidad Nacional de Gral. San Martín, Casilla de Correo 30, 1650 San Martín, Buenos Aires, Argentina. Phone: 54 1 752-0021. Fax: 54 1 752-9639. E-mail: oscar{at}inti.gov.ar.

Clinical and Diagnostic Laboratory Immunology, March 1998, p. 254-255, Vol. 5, No. 2
1071-412X/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


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  • Pitcovsky, T. A., Mucci, J., Alvarez, P., Leguizamon, M. S., Burrone, O., Alzari, P. M., Campetella, O. (2001). Epitope Mapping of trans-Sialidase from Trypanosoma cruzi Reveals the Presence of Several Cross-Reactive Determinants. Infect. Immun. 69: 1869-1875 [Abstract] [Full Text]  
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