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Clinical and Diagnostic Laboratory Immunology, May 1998, p. 308-312, Vol. 5, No. 3
1071-412X/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

In Vitro p24 Antigen-Stimulated Lymphocyte Proliferation and beta -Chemokine Production in Human Immunodeficiency Virus Type 1 (HIV-1)-Seropositive Subjects after Immunization with an Inactivated gp120-Depleted HIV-1 Immunogen (Remune)

Ronald B. Moss,1,* Mark R. Wallace,2 Paola Lanza,1 Wieslawa Giermakowska,1 Fred C. Jensen,1 Georgia Theofan,1 Carolyn Chamberlin,2 Steven P. Richieri,1 and Dennis J. Carlo1

The Immune Response Corporation, Carlsbad,1 and Division of Infectious Diseases, U.S. Naval Medical Center, San Diego,2 California

Received 29 December 1997/Returned for modification 16 February 1998/Accepted 26 February 1998

We examined the effect of immune stimulation by a human immunodeficiency virus type 1 (HIV-1) immunogen (Remune) compared to a non-HIV vaccine (influenza) on HIV-1-specific immune responses in HIV-1-seropositive subjects. HIV-1 p24 antigen-stimulated lymphocyte proliferation was not augmented after immunization with the influenza vaccine. In contrast, subjects increased their lymphocyte proliferative responses to p24 antigen after one immunization with HIV-1 immunogen (Remune) (gp120-depleted inactivated HIV-1 in incomplete Freund's adjuvant). Furthermore, p24 antigen-stimulated beta -chemokine production (RANTES, MIP-1alpha , MIP-1beta ) was also augmented after immunization with the HIV-1 immunogen but not influenza vaccine. Taken together, these results suggest that in this cohort, HIV-specific immune responses to p24 antigen can be augmented after immunization with an HIV-1 immunogen. The ability to upregulate immune responses to the more conserved core proteins may have important implications in the development of immunotherapeutic interventions for HIV-1 infection.

* Corresponding author. Mailing address: The Immune Response Corp., 5935 Darwin Ct., Carlsbad, CA 92008. Phone: (760) 431-7080. Fax: (760) 431-8636. E-mail: shotdoc{at}imnr.com.

Clinical and Diagnostic Laboratory Immunology, May 1998, p. 308-312, Vol. 5, No. 3
1071-412X/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


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