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Clinical and Diagnostic Laboratory Immunology, May 1998, p. 322-324, Vol. 5, No. 3
1071-412X/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

The Polysaccharide Fucoidin Inhibits the Antibiotic-Induced Inflammatory Cascade in Experimental Pneumococcal Meningitis

Carl Granert,1,* Johan Raud,2,dagger and Lars Lindquist1

Department of Infectious Diseases, Huddinge Hospital, S-141 86 Huddinge,1 and Department of Physiology and Pharmacology, Karolinska Institutet, S-171 77 Stockholm,2 Sweden

Received 28 July 1997/Returned for modification 11 November 1997/Accepted 5 February 1998

There is evidence that the treatment of bacterial meningitis with antibiotics liberates harmful bacterial products in the subarachnoid space (SAS). This enhances meningeal inflammation and in particular the recruitment of leukocytes into the cerebrospinal fluid (CSF), which has been shown to be more harmful than beneficial in this disease. In this study, we used a rabbit meningitis model based on intracisternal injection of live Streptococcus pneumoniae. Ampicillin (40 mg/kg of body weight given intravenously [i.v.] 16 h after induction of meningitis) caused a fivefold increase in CSF leukocytes over a 4-h period. Inhibition of leukocyte rolling by treatment with the polysaccharide fucoidin (10 mg/kg, i.v.) prevented the enhanced leukocyte extravasation into the SAS and attenuated the leakage of plasma proteins over the blood-brain barrier. These results suggest that certain polysaccharides that block leukocyte rolling have the potential to reduce leukocyte-dependent central nervous system damage in bacterial meningitis.

* Corresponding author. Mailing address: Department of Infectious Diseases, Huddinge Hospital, S-141 86 Huddinge, Sweden. Phone: 46-8-585 80000. Fax: 46-8-585 81916.

dagger Present address: Astra Pain Control AB, Preclinical R&D, Novum Unit, S-141 57 Huddinge, Sweden.

Clinical and Diagnostic Laboratory Immunology, May 1998, p. 322-324, Vol. 5, No. 3
1071-412X/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

  • van der Flier, M., Geelen, S. P. M., Kimpen, J. L. L., Hoepelman, I. M., Tuomanen, E. I. (2003). Reprogramming the Host Response in Bacterial Meningitis: How Best To Improve Outcome?. Clin. Microbiol. Rev. 16: 415-429 [Abstract] [Full Text]  
  • Granert, C., Raud, J., Waage, A., Lindquist, L. (1999). Effects of Polysaccharide Fucoidin on Cerebrospinal Fluid Interleukin-1 and Tumor Necrosis Factor Alpha in Pneumococcal Meningitis in the Rabbit. Infect. Immun. 67: 2071-2074 [Abstract] [Full Text]  


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