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Clinical and Diagnostic Laboratory Immunology, May 1998, p. 407-409, Vol. 5, No. 3
1071-412X/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Clinical Evaluation of a Rapid Immunochromatographic Test for the Diagnosis of Dengue Virus Infection

Chew Theng Sang,1 Lim Siew Hoon,1 Andrea Cuzzubbo,2 and Peter Devine3,*

Department of Pathology, Singapore General Hospital, Singapore, Singapore,1 and PanBio Pty., Ltd.,2 and Clinical Sciences, Royal Brisbane Hospital,3 Brisbane, Australia

Received 8 September 1997/Returned for modification 27 October 1997/Accepted 17 February 1998

A rapid immunochromatographic test was compared to the hemagglutination inhibition assay for separate determinations of dengue virus-specific immunoglobulin M (IgM) and IgG levels in paired serum specimens from 92 patients (34 with primary dengue virus infection, 35 with secondary dengue virus infection, and 23 without dengue virus infection). The rapid test showed 99% sensitivity in the diagnosis of dengue virus infection. The majority (30 of 34 [88%]) of patients with primary infection showed positive IgM but negative IgG, while 34 of 35 (97%) patients with secondary infection showed positive IgG with or without IgM. Specificity in nonflavivirus infections was 96% (1 of 23 positive). The rapid test should be a useful aid in rapid diagnosis of dengue virus infection.

* Corresponding author. Mailing address: B Floor, Clinical Sciences, Royal Brisbane Hospital, Herston 4129, Queensland, Australia. Phone: 61-7-33655202. Fax: 61-7-33655203.

Clinical and Diagnostic Laboratory Immunology, May 1998, p. 407-409, Vol. 5, No. 3
1071-412X/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


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