This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Smith, C. A.
Right arrow Articles by Sullivan, K. E.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Smith, C. A.
Right arrow Articles by Sullivan, K. E.

 Previous Article

Clinical and Diagnostic Laboratory Immunology, May 1998, p. 415-417, Vol. 5, No. 3
1071-412X/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Increased Prevalence of Immunoglobulin A Deficiency in Patients with the Chromosome 22q11.2 Deletion Syndrome (DiGeorge Syndrome/Velocardiofacial Syndrome)

Christopher A. Smith,1 Deborah A. Driscoll,2 Beverly S. Emanuel,3 Donna M. McDonald-McGinn,3 Elaine H. Zackai,3 and Kathleen E. Sullivan1,*

Division of Immunologic and Infectious Diseases1 and Division of Human Genetics and Molecular Biology,3 The Children's Hospital of Philadelphia, and Department of Obstetrics and Gynecology, The University of Pennsylvania School of Medicine,2 Philadelphia, Pennsylvania

Received 24 October 1997/Returned for modification 26 December 1997/Accepted 2 March 1998

We wished to determine the prevalence of immunoglobulin A (IgA) deficiency in patients with the chromosome 22q11.2 deletion syndrome. A total of 32 patients with the chromosome 22q11.2 deletion were examined for IgA deficiency. We report a 13% (n = 4) prevalence of IgA deficiency in patients with this syndrome. The odds ratio of IgA deficiency in this population is 14.20 (P < 0.0001). This confirms the occurrence of significant humoral deficits in this predominantly cellular immunodeficiency.

* Corresponding author. Mailing address: Division of Immunologic and Infectious Diseases, The Children's Hospital of Philadelphia, 34th St. and Civic Center Blvd., Philadelphia, PA 19104. Phone: (215) 590-4685. Fax: (215) 590-3044. E-mail: sullivak{at}mail.med.upenn.edu.

Clinical and Diagnostic Laboratory Immunology, May 1998, p. 415-417, Vol. 5, No. 3
1071-412X/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

  • Piliero, L. M., Sanford, A. N., McDonald-McGinn, D. M., Zackai, E. H., Sullivan, K. E. (2004). T-cell homeostasis in humans with thymic hypoplasia due to chromosome 22q11.2 deletion syndrome. Blood 103: 1020-1025 [Abstract] [Full Text]  
  • Gennery, A R, Barge, D, O'Sullivan, J J, Flood, T J, Abinun, M, Cant, A J (2002). Antibody deficiency and autoimmunity in 22q11.2 deletion syndrome. Arch. Dis. Child. 86: 422-425 [Abstract] [Full Text]  
  • Perkins, J. A., Sie, K., Gray, S. (2000). Presence of 22q11 Deletion in Postadenoidectomy Velopharyngeal Insufficiency. Arch Otolaryngol Head Neck Surg 126: 645-648 [Abstract] [Full Text]  
  • Sullivan, K. E., McDonald-McGinn, D., Driscoll, D. A., Emanuel, B. S., Zackai, E. H., Jawad, A. F. (1999). Longitudinal Analysis of Lymphocyte Function and Numbers in the First Year of Life in Chromosome 22q11.2 Deletion Syndrome (DiGeorge Syndrome/Velocardiofacial Syndrome). CVI 6: 906-911 [Abstract] [Full Text]  
  • Vorechovsky, I., Blennow, E., Nordenskjold, M., Webster, A. D. B., Hammarstrom, L. (1999). A Putative Susceptibility Locus on Chromosome 18 Is Not a Major Contributor to Human Selective IgA Deficiency: Evidence from Meiotic Mapping of 83 Multiple-Case Families. J. Immunol. 163: 2236-2242 [Abstract] [Full Text]  
  • Urnovitz, H. B., Tuite, J. J., Higashida, J. M., Murphy, W. H. (1999). RNAs in the Sera of Persian Gulf War Veterans Have Segments Homologous to Chromosome 22q11.2. CVI 6: 330-335 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»