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Clinical and Diagnostic Laboratory Immunology, July 1998, p. 499-502, Vol. 5, No. 4
1071-412X/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Concentrations of Circulating beta -Chemokines Do Not Correlate with Viral Load in Human Immunodeficiency Virus-Infected Individuals

Vellalore N. Kakkanaiah, Emmanuel A. Ojo-Amaize, and James B. Peter

Specialty Laboratories, Santa Monica, California 90404-3900

Received 5 February 1998/Returned for modification 20 March 1998/Accepted 11 May 1998

The CC or beta -chemokines MIP-1alpha , MIP-1beta , and RANTES are the primary components of human immunodeficiency virus type 1 (HIV-1)-suppressive soluble factors in vitro. We studied the relationship between the concentrations of MIP-1alpha , MIP-1beta , and RANTES in plasma and HIV viral load in HIV-infected subjects. The HIV-positive patient group (n = 140) had significantly lower concentrations of all three beta -chemokines (MIP-1alpha , P < 0.0005; MIP-1beta , P < 0.005; RANTES, P < 0.0005) than the control group (n = 58 for MIP-1alpha , n = 27 for MIP-1beta , and n = 59 for RANTES). In addition, we divided the patient group into three subgroups (high, moderate, and low) based on the number of HIV-1 RNA copies in the plasma (as measured by quantitative HIV RNA PCR). Again, all three subgroups had significantly lower concentrations of the beta -chemokines than the HIV-negative control group. However, there was no significant difference in plasma beta -chemokine concentrations among the three subgroups within the patient group (P < 0.3). Although our results demonstrate that HIV-infected individuals had significantly lower concentrations of circulating beta -chemokines than healthy uninfected control subjects, we found no correlation between the concentrations of beta -chemokines in plasma and HIV-1 viral load in HIV-infected individuals.

Clinical and Diagnostic Laboratory Immunology, July 1998, p. 499-502, Vol. 5, No. 4
1071-412X/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


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