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Clinical and Diagnostic Laboratory Immunology, November 1998, p. 888-893, Vol. 5, No. 6
1071-412X/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Accumulation of Acid-Fast Lipochrome Bodies in Glial Cells of the Midbrain Nigral Lesion in Parkinson's Disease

Shunro Kohbata,1,* Tomokazu Tamura,2 and Ryoichi Hayashi3

Department of Microbiology, Gifu University School of Medicine, Tsukasa-machi 40, Gifu City, Gifu 500,1 Department of Internal Medicine, Fuji National Hospital, Kamiide 814, Fujinomiya City, Shizuoka 418-01,2 and Department of Internal Medicine (Neurology), Shinshu University School of Medicine, Asahi 3-1-1, Matumoto City, Nagano 390,3 Japan

Received 10 March 1998/Returned for modification 22 April 1998/Accepted 13 August 1998

To confirm or refute the proposed link between nocardiae and Parkinson's disease (PD), we investigated the presence of acid-fast spherical structures similar to filterable nocardiae at the midbrain nigral lesions of three patients with PD. Many clusters of acid-fast lipochrome bodies were dense around blood vessels in the two patients with Hoehn and Yahr stage II and III PD. These clusters were present in the vicinity of melanin-pigmented neurons in the three PD patients studied. Examination of adjacent hematoxylin-and-eosin-stained sections indicated that they consisted of yellow-green granules, bodies, and aggregates in ballooned glial cells. On the other hand, no clusters of acid-fast lipochrome bodies were observed at the compacta region of three control patients. Our results suggest that the immunological and genetic relationship between the acid-fast lipochrome bodies and filterable nocardiae should be investigated.

* Corresponding author. Mailing address: Department of Microbiology, Gifu University School of Medicine, Tsukasa-machi 40, Gifu City, Gifu 500-8076, Japan. Phone: 81-582-65-1241. Fax: 81-582-67-0156.

Clinical and Diagnostic Laboratory Immunology, November 1998, p. 888-893, Vol. 5, No. 6
1071-412X/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.




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