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Clinical and Diagnostic Laboratory Immunology, November 1998, p. 894-896, Vol. 5, No. 6
1071-412X/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Aging and the Immune Response to Tetanus Toxoid: Diminished Frequency and Level of Cellular Immune Reactivity to Antigenic Stimulation

Desmond Schatz,1 Tamir Ellis,2 Eric Ottendorfer,2 Eric Jodoin,2 Douglas Barrett,1 and Mark Atkinson2,*

Departments of Pediatrics1 and Pathology,2 University of Florida, Gainesville, Florida

Received 24 April 1998/Returned for modification 27 May 1998/Accepted 28 July 1998

The period of efficacious immune reactivity afforded by tetanus immunization and the need for continuing some forms of tetanus vaccination programs have been the subjects of recent debates. Our studies demonstrate that the level of antitetanus immunity based on immunological memory (i.e., cellular immune responsiveness) varies dramatically as a function of age, with older individuals constituting a population which is increasingly susceptible to tetanus infection.

* Corresponding author. Mailing address: Department of Pathology, University of Florida, Box 100275 JHMHC, Gainesville, FL 32610. Phone: (352) 392-0048. Fax: (352) 392-9719. E-mail: atkinson{at}ufl.edu.

Clinical and Diagnostic Laboratory Immunology, November 1998, p. 894-896, Vol. 5, No. 6
1071-412X/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


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