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Clinical and Diagnostic Laboratory Immunology, March 1999, p. 216-223, Vol. 6, No. 2
1071-412X/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Human Herpesviruses in Chronic Fatigue Syndrome

Howard L. Wallace II,1 Benjamin Natelson,2 William Gause,3 and John Hay1,*

Department of Microbiology, State University of New York at Buffalo, Buffalo, New York1; Veterans Administration Medical Center, East Orange, New Jersey2; and Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, Maryland3

Received 6 July 1998/Returned for modification 23 October 1998/Accepted 10 November 1998

We have conducted a double-blind study to assess the possible involvement of the human herpesviruses (HHVs) HHV6, HHV7, Epstein-Barr virus (EBV), and cytomegalovirus in chronic fatigue syndrome (CFS) patients compared to age-, race-, and gender-matched controls. The CFS patient population was composed of rigorously screened civilian and Persian Gulf War veterans meeting the Centers for Disease Control and Prevention's CFS case definition criteria. Healthy control civilian and veteran populations had no evidence of CFS or any other exclusionary medical or psychiatric condition. Patient peripheral blood mononuclear cells were analyzed by PCR for the presence of these HHVs. Using two-tailed Fisher's exact test analyses, we were unable to ascertain any statistically significant differences between the CFS patient and control populations in terms of the detection of one or more of these viruses. This observation was upheld when the CFS populations were further stratified with regard to the presence or absence of major axis I psychopathology and patient self-reported gradual versus acute onset of disease. In tandem, we performed serological analyses of serum anti-EBV and anti-HHV6 antibody titers and found no significant differences between the CFS and control patients.

* Corresponding author. Mailing address: Department of Microbiology, SUNY at Buffalo, 138 Farber Hall, 3435 Main St., Buffalo, NY 14214. Phone: (716) 829-2907. Fax: (716) 829-2158. E-mail: jhay{at}buffalo.edu.

Clinical and Diagnostic Laboratory Immunology, March 1999, p. 216-223, Vol. 6, No. 2
1071-412X/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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