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Clinical and Diagnostic Laboratory Immunology, March 1999, p. 276-278, Vol. 6, No. 2
1071-412X/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Phagocytosis of Vibrio cholerae O139 Bengal by Human Polymorphonuclear Leukocytes

M. John Albert,1,* Firdausi Qadri,1 Nurul A. Bhuiyan,1 Shaikh M. Ahmad,1 M. Ansaruzzaman,1 and Andrej Weintraub2

Laboratory Sciences Division, International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh,1 and Department of Immunology, Microbiology, Pathology, and Infectious Diseases, Division of Clinical and Oral Bacteriology, Karolinska Institute, Huddinge Hospital, S-14186 Huddinge, Sweden2

Received 14 May 1998/Returned for modification 22 June 1998/Accepted 9 December 1998

Capsulated bacteria exhibit serum (complement) resistance and resistance to phagocytosis, which result in disseminated infections. Vibrio cholerae O139 strains possess a thin capsule and have been found to be partially serum resistant in a previous study. In the present study, compared to a standard capsulated Klebsiella pneumoniae strain, which showed total resistance to killing by phagocytosis, V. cholerae O139 strains were shown to be only partially resistant, with most strains showing <40% survival. These findings may explain the relative rarity of V. cholerae O139 bacteremia in cholera caused by this organism.

* Corresponding author. Mailing address: Laboratory Sciences Division, ICDDR,B, GPO Box 128, Dhaka 1000, Bangladesh. Phone: 880 2 602440. Fax: 880 2 872529 or -883116. E-mail: albert{at}icddrb.org.

Clinical and Diagnostic Laboratory Immunology, March 1999, p. 276-278, Vol. 6, No. 2
1071-412X/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

  • Qadri, F., Svennerholm, A.-M., Shamsuzzaman, S., Bhuiyan, T. R., Harris, J. B., Ghosh, A. N., Nair, G. B., Weintraub, A., Faruque, S. M., Ryan, E. T., Sack, D. A., Calderwood, S. B. (2005). Reduction in Capsular Content and Enhanced Bacterial Susceptibility to Serum Killing of Vibrio cholerae O139 Associated with the 2002 Cholera Epidemic in Bangladesh. Infect. Immun. 73: 6577-6583 [Abstract] [Full Text]  
  • Nesper, J., Schild, S., Lauriano, C. M., Kraiss, A., Klose, K. E., Reidl, J. (2002). Role of Vibrio cholerae O139 Surface Polysaccharides in Intestinal Colonization. Infect. Immun. 70: 5990-5996 [Abstract] [Full Text]  


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