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Clinical and Diagnostic Laboratory Immunology, May 1999, p. 352-355, Vol. 6, No. 3
1071-412X/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Immunoglobulin G (IgG) Subclass Distribution and IgG1 Avidity of Antibodies in Human Immunodeficiency Virus-Infected Individuals after Revaccination with Tetanus Toxoid

F. P. Kroon,1,* M. J. D. van Tol,2 C. M. Jol-van der Zijde,2 R. van Furth,1 and J. T. van Dissel1

Department of Infectious Diseases1 and Department of Pediatrics,2 Leiden University Medical Center, Leiden, The Netherlands

Received 22 July 1998/Returned for modification 28 October 1998/Accepted 19 January 1999

In human immunodeficiency virus (HIV)-infected individuals the amount of antibodies formed after vaccination with T-cell-dependent recall antigens such as tetanus toxoid is proportional to the peripheral blood CD4+ T-lymphocyte counts. To investigate whether the immunoglobulin G (IgG) subclass distribution and avidity of the antibodies produced after vaccination are affected as well, we gave 13 HIV-infected adults with low CD4+ T-lymphocyte counts (<200 × 106/liter; group I), 11 HIV-infected adults with intermediate CD4+ T-lymphocyte counts (>= 200 × 106/liter; group II), and 5 healthy controls booster immunizations with tetanus toxoid. The prevaccination antibody concentrations against tetanus toxoid were similar in the HIV-infected and healthy adults. After vaccination the total IgG and the IgG1 anti-tetanus toxoid antibody concentrations were significantly lower in group I than in group II and the controls. The avidity of the IgG1 anti-tetanus toxoid antibodies formed by HIV-infected adults was within the range for healthy controls, irrespective of their CD4+ T-lymphocyte counts.

* Corresponding author. Mailing address: Department of Infectious Diseases (C5P), Leiden University Medical Center, P.O. Box 9600, 2300 RC Leiden, The Netherlands. Phone: 31 71 5262613. Fax: 31 71 5266758. E-mail: kroonfp{at}xs4all.nl.

Clinical and Diagnostic Laboratory Immunology, May 1999, p. 352-355, Vol. 6, No. 3
1071-412X/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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