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Clinical and Diagnostic Laboratory Immunology, May 1999, p. 427-428, Vol. 6, No. 3
1071-412X/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Levels of Proinflammatory Cytokines in Plasma after Pneumoccoccal Immunization in Human Immunodeficiency Virus Type 1-Infected Patients

Hernan Valdez,1,* Scott Purvis,1 Robert Asaad,1 Ian Valerio,1 Beverly E. Sha,2 Alan L. Landay,2 and Michael M. Lederman1

Case Western Reserve University Center for AIDS Research and University Hospitals of Cleveland, Cleveland, Ohio 44106-5083,1 and Rush-Presbyterian-St. Luke's Medical Center, Chicago, Illinois 60612-38332

Received 26 October 1998/Returned for modification 9 December 1998/Accepted 5 February 1999

To ascertain if immunization with pneumococcal polysaccharide vaccine is associated with rises in the levels of proinflammatory cytokines in the plasma of human immunodeficiency virus type 1 (HIV-1)-infected patients, the levels of tumor necrosis factor alpha (TNF-alpha ) and interleukin-6 (IL-6) were measured serially after immunization. IL-6 levels rose an average of 2.2- and 2.1-fold 6 and 8 h after immunization, respectively, but TNF-alpha levels remained unchanged. The levels of these cytokines were stable in unimmunized controls. Immunization with pneumococcal polysaccharide vaccine induces increases in the levels of IL-6 in the plasma of persons with HIV-1 infection.

* Corresponding author. Mailing address: 2061 Cornell Rd., Rm 301 B, Cleveland, OH 44106. Phone: (216) 844-2057. Fax: (216) 844-2370. E-mail: valdez.hernan{at}clevelandactu.org.

Clinical and Diagnostic Laboratory Immunology, May 1999, p. 427-428, Vol. 6, No. 3
1071-412X/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.




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