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Clinical and Diagnostic Laboratory Immunology, November 1999, p. 977-980, Vol. 6, No. 6
1071-412X/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Relative Avidities of Human Immunoglobulin G Antibodies for Streptococcal Pyrogenic Exotoxins A and B

Ellen M. Mascini,* Margriet Jansze, Jan Verhoef, and Hans van Dijk

Eijkman-Winkler Institute for Microbiology, Infectious Diseases, and Inflammation, University Medical Center, Utrecht, The Netherlands

Received 19 February 1999/Returned for modification 21 April 1999/Accepted 1 September 1999

In this pilot study, we investigated the relative avidities for streptococcal pyrogenic exotoxin A (SPE-A) and SPE-B of antibodies in sera from patients with fatal streptococcal toxic shock-like syndrome and from healthy individuals and in intravenous immunoglobulin (IVIG) preparations. We observed a great variation in the relative avidities of patient, control, and IVIG immunoglobulin G (IgG) (values estimated to be between 10-7 and 10-11 M), with mean values for patient IgG about 10-fold lower than those of control IgG.

* Corresponding author. Mailing address: Eijkman-Winkler Institute for Microbiology, Infectious Diseases, and Inflammation, Utrecht University Hospital G04.614, P.O. Box 85500, NL-3508 GA Utrecht, The Netherlands. Phone: 31-302 507627. Fax: 31-302 541770. E-mail: e.m.mascini{at}lab.azu.nl.

Clinical and Diagnostic Laboratory Immunology, November 1999, p. 977-980, Vol. 6, No. 6
1071-412X/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.




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