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Clinical and Diagnostic Laboratory Immunology, May 2000, p. 515-518, Vol. 7, No. 3
1071-412X/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Secretory Leukocyte Protease Inhibitor Inhibits Infection of Monocytes and Lymphocytes with Human Immunodeficiency Virus Type 1 but Does Not Interfere with Transcytosis of Cell-Associated Virus across Tight Epithelial Barriers

Hakim Hocini,1 Pierre Becquart,1 Hicham Bouhlal,1 Homa Adle-Biassette,2 Michel D. Kazatchkine,1,3 and Laurent Bélec1,3,4,*

Unité INSERM U4301 and Laboratoire de Virologie,4 Hôpital Broussais, and Université Pierre et Marie Curie (Paris VI),3 Paris, and Département de Pathologie, Université Paris-Sud (Paris XII), Hôpital Henri Mondor, Créteil,2 France

Received 21 October 1999/Returned for modification 19 January 2000/Accepted 28 February 2000

In the present study, we demonstrate that recombinant human secretory leukocyte protease inhibitor (rhSLPI) inhibits infection of lymphocyte- and monocyte-derived tumor cell lines and peripheral blood lymphocytes with laboratory-adapted isolates and with the primary isolate, NDK, of free human immunodeficiency virus type 1 (HIV-1). In contrast, rhSLPI did not exhibit inhibitory activity toward transcytosis of cell-associated HIV-1 through a tight monolayer of endometrial epithelial cells. These observations indicate that the inhibitory effect of SLPI is restricted to free HIV-1 in corporal fluids.

* Corresponding author. Mailing address: Unité INSERM U430, Hôpital Broussais, 96, rue Didot, 75674 Paris Cedex 14, France. Phone: 331 43 95 80 53. Fax: 331 43 95 80 55. E-mail: laurent.belec{at}brs.ap-hop-paris.fr.

Clinical and Diagnostic Laboratory Immunology, May 2000, p. 515-518, Vol. 7, No. 3
1071-412X/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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