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Clinical and Diagnostic Laboratory Immunology, July 2000, p. 584-587, Vol. 7, No. 4
1071-412X/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Serologic Testing for Celiac Disease in the United States: Results of a Multilaboratory Comparison Study

Joseph A. Murray,1,* Judith Herlein,2 Frank Mitros,2 and James A. Goeken2

Departments of Internal Medicine1 and Pathology,2 University of Iowa College of Medicine, and the Department of Veterans Affairs Medical Center, Iowa City, Iowa

Received 12 July 1999/Returned for modification 25 October 1999/Accepted 14 April 2000

The aim of this study was to compare the efficiencies of six reference laboratories for serologic testing for celiac disease. Serum from 20 patients with untreated celiac disease and from 20 controls was thawed, divided, and distributed to each participating laboratory, which performed endomysial antibody tests. Five laboratories also performed antigliadin antibody tests. Sensitivity for endomysial antibody immunoglobulin A (IgA) varied from 57 to 90%. In all laboratories, the specificity for celiac disease was 100%. The sensitivity and specificity for both IgA and IgG antigliadin antibody varied significantly. When results from all three tests were combined in each laboratory, sensitivity was 90 to 100%. The specificity for endomysial antibody was 100% in the laboratories. Sensitivity was less than reported previously. Standardization of these tests is needed in the United States.

* Corresponding author. Present address: Division of Gastroenterology and Hepatology and Internal Medicine, Mayo Clinic, 200 First St. SW, Rochester, MN 55905.

Clinical and Diagnostic Laboratory Immunology, July 2000, p. 584-587, Vol. 7, No. 4
1071-412X/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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