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Clinical and Diagnostic Laboratory Immunology, July 2000, p. 710-713, Vol. 7, No. 4
1071-412X/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

CD4+ Lymphocyte-Mediated Suppression of Cytomegalovirus Expression in Human Astrocytes

Maxim C.-J. Cheeran,1,2 Genya Gekker,1,3 Shuxian Hu,1,3 Stephanie L. Yager,1 Phillip K. Peterson,1,2,3 and James R. Lokensgard1,3,*

Institute for Brain and Immune Disorders, Minneapolis Medical Research Foundation,1 and University of Minnesota Medical School,3 Minneapolis, Minnesota 55404, and the College of Veterinary Medicine, University of Minnesota, St. Paul, Minnesota 551082

Received 17 December 1999/Returned for modification 25 February 2000/Accepted 8 May 2000

Cytomegalovirus-stimulated CD4+ lymphocytes from seropositive but not seronegative donors suppressed viral gene expression in primary human astrocytes. This suppressive activity was mediated through soluble factors. These findings suggest that CD4+ lymphocytes play a role in defense of the brain against cytomegalovirus.

* Corresponding author. Mailing address: Minneapolis Medical Research Foundation, 914 South 8th St., Bldg. D-3, Minneapolis, MN 55404. Phone: (612) 347-6849. Fax: (612) 337-7372. E-mail: loken006{at}tc.umn.edu.

Clinical and Diagnostic Laboratory Immunology, July 2000, p. 710-713, Vol. 7, No. 4
1071-412X/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

  • Cheeran, M. C.-J., Hu, S., Sheng, W. S., Peterson, P. K., Lokensgard, J. R. (2003). CXCL10 Production from Cytomegalovirus-Stimulated Microglia Is Regulated by both Human and Viral Interleukin-10. J. Virol. 77: 4502-4515 [Abstract] [Full Text]  


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