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Clinical and Diagnostic Laboratory Immunology, September 2000, p. 842-844, Vol. 7, No. 5
1071-412X/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Prevalence of CagA and VacA Antibodies in Children with Helicobacter pylori-Associated Peptic Ulcer Compared to Prevalence in Pediatric Patients with Active or Nonactive Chronic Gastritis

T. Alarcón,1,* M. J. Martínez,2 P. Urruzuno,3 M. L. Cilleruelo,4 D. Madruga,5 M. Sebastian,6 D. Domingo,1 J. C. Sanz,7 and M. López-Brea1

Department of Microbiology, Hospital Universitario de la Princesa,1 Gastroenterology Unit, Hospital del Niño Jesús,2 Gastroenterology Unit, Hospital 12 Octubre,3 Gastroenterology Unit, Hospital Severo Ochoa,4 Gastroenterology Unit, Hospital de Getafe,5 Gastroenterology Unit, Hospital de Móstoles,6 and Laboratorio de Salud Pública, Comunidad de Madrid,7 Madrid, Spain

Received 3 February 2000/Returned for modification 21 March 2000/Accepted 10 July 2000

VacA and CagA serological responses were detected in pediatric patients: 44 and 56%, respectively, in peptic ulcer (PU) patients, 33.3 and 44.4% in active chronic gastritis (ACG) patients, and 23.2 and 39.2% in non-ACG patients. Higher seroprevalence to CagA+VacA and to CagA+VacA+35-kDa antigen was found among PU patients. However, a low level of sensitivity and specificity was found for indirect detection of PU patients.

* Corresponding author. Mailing address: Dep. Microbiology, Hospital Universitario de la Princesa, Diego de León 62, 28006 Madrid, Spain. Phone: 34 91 520 23 17. Fax: 34 91 309 00 47. E-mail: talarcon{at}helicobacterspain.com.

Clinical and Diagnostic Laboratory Immunology, September 2000, p. 842-844, Vol. 7, No. 5
1071-412X/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.




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