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Clinical and Diagnostic Laboratory Immunology, September 2000, p. 856-857, Vol. 7, No. 5
1071-412X/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Human Dengue Antibodies against Structural and Nonstructural Proteins

Katia Valdés, Mayling Alvarez, Maritza Pupo, Susana Vázquez, Rayner Rodríguez, and María G. Guzmán*

Department of Virology, PAHO/WHO Collaborating Center for Viral Diseases, "Pedro Kouri" Tropical Medicine Institute, Autopista Novia del Mediodía, Marianao 13, Havana, Cuba

Received 27 January 2000/Returned for modification 17 March 2000/Accepted 31 May 2000

Antibodies against dengue virus type 2 and 4 proteins in acute-phase sera of 10 primary and 10 secondary dengue fever and dengue hemorrhagic fever patients were studied by Western blotting. In the first group the immune response was barely detectable, while in the second group more proteins were detected, with a very strong reaction. Anti-NS1 and -NS3 antibodies were detected mainly in secondary cases. Anti-E, -NS3, and -NS5 antibodies were detected in a high number of cases. The possibility of implementing early diagnostic assays for antigen detection is suggested.

* Corresponding author. Mailing address: Department of Virology, PAHO/WHO Collaborating Center for Viral Diseases, "Pedro Kouri" Tropical Medicine Institute, Autopista Novia del Mediodía, km 6, P.O. Box 601, Marianao 13, Havana, Cuba. Phone: 53-7-220633. Fax: 53-7-246051. Email: lupe{at}ipk.sld.cu.

Clinical and Diagnostic Laboratory Immunology, September 2000, p. 856-857, Vol. 7, No. 5
1071-412X/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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