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Clinical and Diagnostic Laboratory Immunology, November 2000, p. 885-888, Vol. 7, No. 6
Arctic Investigations Program, National
Center for Infectious Diseases, Centers for Disease Control and
Prevention, Public Health Service, U.S. Department of Health and Human
Services, Anchorage, Alaska,1 and
Division of Bacterial and Mycotic Diseases, National Center
for Infectious Diseases, Centers for Disease Control and
Prevention,2 and Division of Pediatric
Gastroenterology and Nutrition, Department of Pediatrics, Emory
University School of Medicine,3 Atlanta, Georgia
Received 20 December 1999/Returned for modification 21 March
2000/Accepted 4 August 2000
Iron deficiency anemia is a common public health problem in the
Alaska Native population. Yet, a clear etiology has eluded researchers
for decades. Previous studies suggested a link between Helicobacter pylori infection, gastrointestinal blood loss
due to hemorrhagic gastritis, and generalized iron deficiency anemia in
adult Alaska Natives. Therefore, we examined the association between
the prevalence of H. pylori-specific immunoglobulin G (IgG)
and serum ferritin levels, a marker of iron deficiency. A random sample
of 2,080 serum samples from Alaska Native residents drawn between 1980 and 1986 from residents in 13 regions was selected, and the samples
were stratified by age, sex, and region. Overall, 75% were positive
for H. pylori-specific IgG. The rate of H. pylori seropositivity increased with age; by age 14 years, 78%
of the residents were positive. There were no gender differences in
H. pylori seropositivity. However, marked regional
differences were observed. Serum ferritin levels of <12 ng/ml were
found most commonly among persons <20 years of age and among women of
childbearing age. A significant association between low serum ferritin
levels and prevalence of H. pylori-specific IgG was found,
particularly for people aged less than 20 years. H. pylori
may be a factor contributing to the iron deficiency anemia in the
Alaska Native population.
1071-412X/00/$04.00+0
High Prevalence of Helicobacter pylori in the Alaska
Native Population and Association with Low Serum Ferritin Levels in
Young Adults
*
Corresponding author. Mailing address: Arctic
Investigations Program, National Center for Infectious Diseases,
Centers for Diseases Control and Prevention, 4055 Tudor Centre Drive,
Anchorage, AK 99508. Phone: (907) 729-3407. Fax: (907) 729-3429. E-mail: ajp1{at}cdc.gov.
Clinical and Diagnostic Laboratory Immunology, November 2000, p. 885-888, Vol. 7, No. 6
1071-412X/00/$04.00+0
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