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Clinical and Diagnostic Laboratory Immunology, January 2001, p. 178-180, Vol. 8, No. 1
1071-412X/01/$04.00+0   DOI: 10.1128/CDLI.8.1.178-180.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Assessment of Neutrophil Function in Patients with Septic Shock: Comparison of Methods

C. Wenisch,1,2,* P. Fladerer,2 S. Patruta,1 R. Krause,2 and W. Hörl3

Division of Infectious Diseases, Department of Internal Medicine I,1 and Division of Nephrology, Department of Internal Medicine III,3 University Hospital of Vienna, Vienna, and Division of Infectious Diseases, Department of Medicine, University Hospital of Graz, Graz,2 Austria

Received 13 June 2000/Returned for modification 14 July 2000/Accepted 5 October 2000

Patients with septic shock are shown to have decreased neutrophil phagocytic function by multiple assays, and their assessment by whole-blood assays (fluorescence-activated cell sorter analysis) correlates with assays requiring isolated neutrophils (microscopic and spectrophotometric assays). For patients with similar underlying conditions but without septic shock, this correlation does not occur.

* Corresponding author. Mailing address: Division of Infectious Diseases, Department of Medicine, University Hospital Graz, Auenbruggerplatz 15, A-8036 Graz, Austria. Phone: 43-316-385-2274. Fax: 43-316-385-4622. E-mail: christoph.wenisch{at}kfunigraz.ac.at.

Clinical and Diagnostic Laboratory Immunology, January 2001, p. 178-180, Vol. 8, No. 1
1071-412X/01/$04.00+0   DOI: 10.1128/CDLI.8.1.178-180.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.




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