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Clinical and Diagnostic Laboratory Immunology, March 2001, p. 333-338, Vol. 8, No. 2
1071-412X/01/$04.00+0   DOI: 10.1128/CDLI.8.2.333-338.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Ageing Is Associated with a Prolonged Fever Response in Human Endotoxemia

Karen Suárez Krabbe,1 Helle Bruunsgaard,1 Christian Muff Hansen,1 Kirsten Møller,1 Lise Fonsmark,1 Jesper Qvist,1 Per Lav Madsen,1 Gitte Kronborg,1 Henrik Ørbaek Andersen,2 Peter Skinhøj,1 and Bente Klarlund Pedersen1,*

Department of Infectious Diseases M7641,1 and Department of Cardiac Catheterization, Laboratory B2014,2 Rigshospitalet, University of Copenhagen, Copenhagen, Denmark

Received 12 July 2000/Returned for modification 6 September 2000/Accepted 1 December 2000

The purpose of this study was to investigate whether an age-associated impaired acute-phase response exists. Nine healthy elderly volunteers (median, 66 years; range, 61 to 69 years) and eight young controls (median, 24 years; range, 20 to 27 years) were given an intravenous bolus of endotoxin (2 ng/kg). The rectal temperature was monitored continuously, and blood samples for cytokine measurements were obtained before endotoxin administration as well as 0.5, 1, 1.5, 2, 3, 4, 8, 12, and 24 h after the injection. The elderly subjects showed a more prolonged fever response compared to the young controls. Levels of tumor necrosis factor alpha (TNF-alpha ), soluble TNF receptors (sTNFR-I), interleukin-6 (IL-6), IL-8, IL-10, and IL-1 receptor antagonist (IL-1ra) in plasma increased markedly following endotoxin administration in both groups. The elderly group showed larger initial increases in TNF-alpha and sTNFR-I levels and prolonged increased levels of sTNFR-I. Monocyte concentrations decreased in both groups, with the elderly group showing a more rapid decrease and a slower subsequent increase than did the young group. Furthermore, the elderly group had a more rapid increase in C-reactive protein levels than did the young group. In conclusion, ageing is associated with an altered acute-phase response including initial hyperreactivity, prolonged inflammatory activity, and prolonged fever response.

* Corresponding author. Mailing address: Department of Infectious Diseases M7641, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen Ø, Denmark. Phone: (45) 3545 7797. Fax: (45) 3545 7644. E-mail: bkp{at}rh.dk.

Clinical and Diagnostic Laboratory Immunology, March 2001, p. 333-338, Vol. 8, No. 2
1071-412X/01/$04.00+0   DOI: 10.1128/CDLI.8.2.333-338.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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