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Clinical and Diagnostic Laboratory Immunology, March 2001, p. 446-448, Vol. 8, No. 2
1071-412X/01/$04.00+0   DOI: 10.1128/CDLI.8.2.446-448.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Cytokine Expression in the Mouse Brain in Response to Immune Activation by Corynebacterium parvum

W. S. Sheng,* S. Hu, J. M. Ding, C. C. Chao, and P. K. Peterson

Institute for Brain and Immune Disorders, Minneapolis Medical Research Foundation, and the University of Minnesota Medical School, Minneapolis, Minnesota 55404

Received 19 June 2000/Returned for modification 28 August 2000/Accepted 22 November 2000

Cytokine expression in the brain has been suggested to mediate various sickness behaviors. Here we report that intraperitoneal injection of a Corynebacterium parvum antigen in C57BL/6 mice was followed by prolonged upregulation of cytokines in the cerebral cortex and subcortical structures in a time course that coincided with reduced spontaneous running activity.

* Corresponding author. Mailing address: Institute for Brain and Immune Disorders, Minneapolis Medical Research Foundation, NeuroImmunology Lab, D-305, 914 South 8th St., D-3, Minneapolis, MN 55404. Phone: (612) 337-7376. Fax: (612) 337-7372. E-mail: wsheng{at}biosci.cbs.umn.edu.

Clinical and Diagnostic Laboratory Immunology, March 2001, p. 446-448, Vol. 8, No. 2
1071-412X/01/$04.00+0   DOI: 10.1128/CDLI.8.2.446-448.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.




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