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Clinical and Diagnostic Laboratory Immunology, March 2001, p. 449-453, Vol. 8, No. 2
1071-412X/01/$04.00+0   DOI: 10.1128/CDLI.8.2.449-453.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Suppression of Endotoxin- and Staphylococcal Exotoxin-Induced Cytokines and Chemokines by a Phospholipase C Inhibitor in Human Peripheral Blood Mononuclear Cells

Teresa Krakauer*

Department of Immunology and Molecular Biology, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland 21702-5011

Received 7 August 2000/Returned for modification 17 October 2000/Accepted 8 December 2000

Excessive release of proinflammatory cytokines from cells stimulated with lipopolysaccharide (LPS) or staphylococcal exotoxin (SE) mediates the pathophysiologic manifestations of septic shock. Tricyclodecan-9-yl (D609), an inhibitor of phosphatidylcholine-specific phospholipase C, suppressed LPS- or SE-induced cytokines and chemokines in human peripheral blood mononuclear cells. These data suggest a potential role for D609 in the treatment of septic shock.

* Mailing address: Department of Immunology and Molecular Biology, 1425 Porter St., USAMRIID, Fort Detrick, MD 21702-5011. Phone: (301) 619-4733. Fax: (301) 619-2348. E-mail: teresa.krakauer{at}det.amedd.army.mil.

Clinical and Diagnostic Laboratory Immunology, March 2001, p. 449-453, Vol. 8, No. 2
1071-412X/01/$04.00+0   DOI: 10.1128/CDLI.8.2.449-453.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.




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