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Clinical and Diagnostic Laboratory Immunology, July 2001, p. 731-739, Vol. 8, No. 4
Division of Bacteriology, Department of
Infectious Disease Control and International Medicine, Niigata
University School of Medical and Dental Sciences, Asahimachidori,
Niigata,1 and Department of
Pediatrics, School of Medicine, Juntendo University,
Tokyo,2 Japan
Received 1 September 2000/Returned for modification 25 January
2001/Accepted 2 April 2001
Biopsy specimens of the antrum and corpus were obtained from four
Helicobacter pylori-infected members of a family and from the same boy (son 1) in whom the infection reappeared after
simultaneous successful eradication treatment of three family members,
excluding the mother. A total of 18 to 60 H. pylori
isolates were obtained from each specimen and subjected to rRNA gene
restriction pattern analysis. The father's isolates and the initial
isolates from son 1 showed the same HindIII type, which was
divided into three HaeIII subtypes. Isolates from the
mother and a brother (son 2) and posttreatment isolates from son 1 showed a distinct HindIII type (with one minor subtype),
which was divided into six HaeIII subtypes. All subtypes of
the initial isolates from son 1 were present in the father's isolates,
and all subtypes of the posttreatment isolates from son 1 were present
in the mother's isolates but not in son 2's. Electron microscopic
analysis of the biopsy specimens demonstrated extremely high levels of
H. pylori colonization in the father's gastric mucosa.
H. pylori adherence with a ruffle formation was also
demonstrated. The findings suggest that son 1 was infected initially
with the H. pylori strain of the father and son 2 was
infected with the H. pylori strain of the mother and that
after eradication therapy son 1 was reinfected with the H. pylori strain of the mother, who did not undergo eradication therapy.
1071-412X/01/$04.00+0 DOI: 10.1128/CDLI.8.4.731-739.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.
Helicobacter pylori Intrafamilial
Infections: Change in Source of Infection of a Child from Father to
Mother after Eradication Therapy
*
Corresponding author. Mailing address: Division of
Bacteriology, Department of Infectious Disease Control and
International Medicine, Niigata University School of Medical and Dental
Sciences, 757 Ichibanchou, Asahimachidori, Niigata, Japan. Phone:
81-25-227-2050. Fax: 81-25-227-0762. E-mail:
tatsuoy{at}med.niigata-u.ac.jp.
Clinical and Diagnostic Laboratory Immunology, July 2001, p. 731-739, Vol. 8, No. 4
1071-412X/01/$04.00+0 DOI: 10.1128/CDLI.8.4.731-739.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.
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