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Clinical and Diagnostic Laboratory Immunology, September 2001, p. 1021-1023, Vol. 8, No. 5
1071-412X/01/$04.00+0   DOI: 10.1128/CDLI.8.5.1021-1023.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Expression of Natural Peptide Antibiotics in Human Articular Cartilage and Synovial Membrane

Friedrich Paulsen,1,* Thomas Pufe,1 Wolf Petersen,2 and Bernhard Tillmann1

Departments of Anatomy1 and Orthopedics,2 Christian Albrecht University of Kiel, Kiel, Germany

Received 26 January 2001/Returned for modification 9 April 2001/Accepted 7 June 2001

In view of frequent present use of invasive procedures on limb joints, it is astonishing that articular joint inflammation is a rare event. We questioned whether antimicrobial peptides play a role in protecting human articular cartilage and synovial membrane against inflammatory agents. Our results implicate defensins in the protection of human articular joints against pathogens.

* Corresponding author. Mailing address: Department of Anatomy, Christian Albrecht University of Kiel, Olshausenstr. 40, 24098 Kiel, Germany. Phone: 494318802597. Fax: 494318801557. E-mail: fpaulsen{at}anat.uni-kiel.de.

Clinical and Diagnostic Laboratory Immunology, September 2001, p. 1021-1023, Vol. 8, No. 5
1071-412X/01/$04.00+0   DOI: 10.1128/CDLI.8.5.1021-1023.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.




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