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Clinical and Diagnostic Laboratory Immunology, November 2001, p. 1286-1288, Vol. 8, No. 6
1071-412X/01/$04.00+0   DOI: 10.1128/CDLI.8.6.1286-1288.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Correlation of CD4+ T-Cell Counts Estimated by an Immunocapture Technique (Capcellia) with Viral Loads in Human Immunodeficiency Virus-Seropositive Individuals

R. Kannangai,1 S. Ramalingam,1 M. V. Jesudason,2 T. S. Vijayakumar,1 O. C. Abraham,3 A. Zachariah,3 and G. Sridharan1,*

Departments of Clinical Virology,1 Clinical Microbiology,2 and Internal Medicine (Unit I),3 Christian Medical College Hospital, Vellore 632004, India

Received 8 May 2001/Returned for modification 16 July 2001/Accepted 10 August 2001

As antiretroviral therapy becomes more affordable, valid, reliable, and inexpensive laboratory tests are also needed to monitor the progression of disease in people with human immunodeficiency virus (HIV) infection. The CD4+ T-cell counts estimated by Capcellia, an immunocapture method, and flow cytometry were compared and were correlated with HIV type 1 (HIV-1) load. There was a significant negative correlation between the HIV-1 load and CD4+ T-cell counts estimated by flow cytometry (r = -0.63, P = <0.001) as well as between the HIV-1 load and CD4+ T-cell counts estimated by Capcellia (r = -0.61, P = <0.001). Capcellia is a cost-effective, user-friendly assay that correlated well with HIV-1 load determinations for individuals both with and without treatment.

* Corresponding author. Mailing address: Department of Clinical Virology, Christian Medical College Hospital, Vellore, India 632004. Phone: 91 416 222102, ext. 2070. Fax: 91 416 232035. E-mail: g_sridharan{at}yahoo.com.

Clinical and Diagnostic Laboratory Immunology, November 2001, p. 1286-1288, Vol. 8, No. 6
1071-412X/01/$04.00+0   DOI: 10.1128/CDLI.8.6.1286-1288.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.




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