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Clinical and Diagnostic Laboratory Immunology, January 2002, p. 164-166, Vol. 9, No. 1
1071-412X/01/$04.00+0     DOI: 10.1128/CDLI.9.1.164-166.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Serum S100B Levels in Patients with Lupus Erythematosus: Preliminary Observation

Luis V. C. Portela,1,2* João C. T. Brenol,3 Roger Walz,2,{dagger} Marino Bianchin,4 Adriano B. L. Tort,2 Ubirajara P. Canabarro,3 Simone Beheregaray,3 João A. Marasca,3 Ricardo M. Xavier,3 Eurico C. Neto,5 Carlos A. Gonçalves,2 and Diogo O. Souza2

Laboratório Municipal de Novo Hamburgo, Novo Hamburgo,1 Departamento Bioquímica, ICBS, Universidade Federal do Rio Grande do Sul,2 Serviço de Reumatologia, Hospital de Clínicas de Porto Alegre,3 Laboratório Nobel RIE, Porto Alegre, Rio Grande do Sul,5 Hospital Regional de São José, São José, Santa Catarina, Brazil4

Received 23 May 2001/ Returned for modification 5 September 2001/ Accepted 11 October 2001

S100B is an astrocytic calcium-binding protein which has been proposed as a biochemical marker of brain damage or dysfunction in acute and chronic diseases. We investigated whether serum S100B levels could be related to systemic lupus erythematosus (SLE) activity. Patients were grouped as having inactive SLE (ISLE), active SLE without central nervous system (CNS) involvement (ASLE), or active SLE with unequivocal neurologic or psychiatric manifestation (NPSLE). The control group consisted of age- and sex-matched healthy blood donors. S100B levels were determined using a luminescence immunoassay. All SLE groups had higher levels of serum S100B than the control group. Among the SLE groups, significantly higher levels of serum S100B protein were found in the NPSLE group than in the ISLE and ASLE groups, and there was no significant difference in S100B levels between the ISLE and ASLE groups. These preliminary results point to a putative relevance of serum S100B protein levels in SLE patients, specifically concerning CNS involvement present in this disease.

* Corresponding author. Mailing address: Departamento de Bioquímica, ICBS, UFRGS, Rua Ramiro Barcelos, 2600 Anexo, 90035-003 Porto Alegre, RS, Brazil. Phone: 55 51 33165558. Fax: 55 51 33165540. E-mail: roska{at}vortex.ufrgs.br.

{dagger} Present address: Centro de Cirurgia de Epilepsia, CIREP, Hospital de Clínicas, Universidade de São Paulo, Ribeirão Preto, SP, Brazil.

Clinical and Diagnostic Laboratory Immunology, January 2002, p. 164-166, Vol. 9, No. 1
1071-412X/01/$04.00+0     DOI: 10.1128/CDLI.9.1.164-166.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Portela, L. V.C., Tort, A. B.L., Schaf, D. V., Ribeiro, L., Nora, D. B., Walz, R., Rotta, L. N., Silva, C. T., Busnello, J. V., Kapczinski, F., Goncalves, C. A., Souza, D. O. (2002). The Serum S100B Concentration Is Age Dependent. Clin. Chem. 48: 950-952 [Full Text]  


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