This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Martin, C. A.
Right arrow Articles by Keren, D. F.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Martin, C. A.
Right arrow Articles by Keren, D. F.

 Previous Article  |  Next Article 

Clinical and Diagnostic Laboratory Immunology, January 2002, p. 187-189, Vol. 9, No. 1
1071-412X/01/$04.00+0     DOI: 10.1128/CDLI.9.1.187-189.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Comparison of Murex Single-Use Diagnostic System with Traditional Enzyme Immunoassay for Detection of Exposure to Human Immunodeficiency Virus

Christin A. Martin1 and David F. Keren2*

Department of Pathology, The University of Michigan Medical School,1 Warde Medical Laboratory, Ann Arbor, Michigan2

Received 29 March 2001/ Returned for modification 11 June 2001/ Accepted 26 September 2001

Because a retrospective study detected 13 negative Western blots out of 38 single-use diagnostic system (SUDS)-positive cases over a 1-year period, we performed a prospective study to compare the performance of the SUDS test with that of enzyme immunoassay (EIA). Of 888 SUDS-tested sera, 875 (98.4%) were both SUDS and EIA negative and 5 (0.6%) were SUDS, EIA, and Western blot positive. The rate of SUDS-positive samples decreased from 3.16/month in the retrospective study to 1.33/month in the prospective study. The immunoassays had sensitivities and specificities of 100 and 99.7 (SUDS) and 100 and 99.4% (traditional EIA), respectively. In laboratories with experienced personnel, the SUDS test performs as well as the EIA as a screen for infection with the human immunodeficiency virus.

* Corresponding author. Mailing address: Warde Medical Laboratory, 5025 Venture Dr., Ann Arbor, MI 48108. Phone: (734) 665-8300. Fax: (734) 665-8380. E-mail: dfkeren{at}yahoo.com.

Clinical and Diagnostic Laboratory Immunology, January 2002, p. 187-189, Vol. 9, No. 1
1071-412X/01/$04.00+0     DOI: 10.1128/CDLI.9.1.187-189.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.





Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»