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Clinical and Diagnostic Laboratory Immunology, January 2002, p. 54-59, Vol. 9, No. 1
1071-412X/01/$04.00+0     DOI: 10.1128/CDLI.9.1.54-59.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Bacteroides ovatus as the Predominant Commensal Intestinal Microbe Causing a Systemic Antibody Response in Inflammatory Bowel Disease

Shin Saitoh,1,2 Satoshi Noda,1 Yuji Aiba,1 Atsushi Takagi,2 Mitsuo Sakamoto,3 Yoshimi Benno,3 and Yasuhiro Koga1*

Departments of Infectious Diseases,1 Internal Medicine, Tokai University School of Medicine, Isehara, Kanagawa 259-1193,2 Collection of Microorganisms, The Institute of Physical and Chemical Research, Wako, Saitama 351-01, Japan3

Received 21 May 2001/ Returned for modification 14 August 2001/ Accepted 13 September 2001

To clarify what bacterial species of commensal intestinal microbes are recognized as the antigens that induce a serum antibody response in patients with inflammatory bowel disease (IBD), 72 subjects consisting of 12 Crohn’s disease patients, 30 ulcerative colitis patients, and 30 healthy volunteers were examined for their titers of serum antibody to these intestinal bacteria. In IBD patients, as a result, significant elevations of both the immunoglobulin G (IgG) and IgA titers to Bacteroides ovatus were found. Immunoblotting showed that a definite 19.5-kDa band of B. ovatus was bound to the serum antibody raised in IBD patients. It was thus concluded that B. ovatus causes serum antibody responses in IBD patients, and a 19.5-kDa molecule of this bacterium appears to be the responsible antigen, although the role of this event in pathogenesis remains unclear.

* Corresponding author. Mailing address: Department of Infectious Diseases, Tokai University School of Medicine, Isehara, Kanagawa 259-1193, Japan. Phone: 81-(0) 463-93-1121, ext. 2591. Fax: 81-(0) 463-94-2976. E-mail: yasuhiro{at}is.icc.u-tokai.ac.jp.

Clinical and Diagnostic Laboratory Immunology, January 2002, p. 54-59, Vol. 9, No. 1
1071-412X/01/$04.00+0     DOI: 10.1128/CDLI.9.1.54-59.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.





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