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Clinical and Diagnostic Laboratory Immunology, March 2002, p. 388-393, Vol. 9, No. 2
1071-412X/02/$04.00+0     DOI: 10.1128/CDLI.9.2.388-393.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Neutralizing Antibody Responses to Human Herpesviruses 6 and 7 Do Not Cross-React with Each Other, and Maternal Neutralizing Antibodies Contribute to Sequential Infection with These Viruses in Childhood

Mariko Yoshida,1* Sadayoshi Torigoe,2 Kumiko Ikeue,1 and Masao Yamada1

Department of Virology, Okayama University Graduate School of Medicine and Dentistry, Okayama,1 Yokkaichi Social Insurance Hospital, Mie, Japan2

Received 8 August 2001/ Returned for modification 2 November 2001/ Accepted 28 November 2001

Seroprevalence of human herpesvirus 6 (HHV-6) and HHV-7 infections is very high throughout the world, and almost all people are exposed first to HHV-6 and second to HHV-7 in their childhood. However, it is not clear whether the neutralizing (NT) antibody response between each virus is cross-reactive or not. To elucidate the NT antibody response between each virus, 55 serum samples from an adult group (subjects 22 to 88 years old) and 60 serum samples from a young group (subjects 2 to 18 years old) were examined by a dot blot method for detecting viral late antigen. Thirty-nine serum samples obtained from cord bloods and a few serum samples obtained from pediatric patients with exanthem subitum were also examined to assess the maternal transferred NT antibodies against each virus. The NT antibody titers against HHV-7 in the adult group remained high throughout all the individuals, and none were negative. Those against HHV-6 were high values in the young group but low values, including negative values (three samples), in the adult group. These results suggested that the NT antibody response to either HHV-6 or HHV-7 in each individual was specific to each virus and did not cross-react with each other. In the adult group, the NT antibody response to HHV-6 decreased, while that to HHV-7 remained high throughout all the individuals. Maternal transferred NT antibody titers against HHV-7 were higher and remained longer after birth than those of HHV-6, and these findings were in accord with the clinical observation that HHV-6 infection usually occurs earlier than HHV-7 infection.

* Corresponding author. Mailing address: Department of Virology, Okayama University Graduate School of Medicine and Dentistry, 2-5-1 Shikatacho, Okayama 700-8558, Japan. Phone: 81-86-235-7167. Fax: 81-86-235-7169. E-mail: mariko{at}md.okayama-u.ac.jp.

Clinical and Diagnostic Laboratory Immunology, March 2002, p. 388-393, Vol. 9, No. 2
1071-412X/02/$04.00+0     DOI: 10.1128/CDLI.9.2.388-393.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Yoshida, M., Torigoe, S., Yamada, M. (2002). Elucidation of the Cross-Reactive Immunoglobulin M Response to Human Herpesviruses 6 and 7 on the Basis of Neutralizing Antibodies. CVI 9: 394-402 [Abstract] [Full Text]  


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