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Clinical and Diagnostic Laboratory Immunology, March 2002, p. 394-402, Vol. 9, No. 2
1071-412X/02/$04.00+0     DOI: 10.1128/CDLI.9.2.394-402.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Elucidation of the Cross-Reactive Immunoglobulin M Response to Human Herpesviruses 6 and 7 on the Basis of Neutralizing Antibodies

Mariko Yoshida,1* Sadayoshi Torigoe,2 and Masao Yamada1

Department of Virology, Okayama University Graduate School of Medicine and Dentistry, Okayama,1 Yokkaichi Social Insurance Hospital, Mie, Japan2

Received 23 July 2001/ Returned for modification 9 May 2001/ Accepted 29 October 2001

Human herpesvirus 6 (HHV-6) is closely related to HHV-7 in terms of genome organization and sequence. The cross-reactive responses between HHV-6 and HHV-7 have been reported by using immunofluorescent techniques. Recently we have shown that neutralizing (NT) antibody responses are specific to each virus and do not cross-react. We took advantage of this and used the NT antibody response to estimate the time of seroconversion to each virus and examined the pattern of humoral immune response, especially the immunoglobulin M (IgM) response, against each virus antigen in the natural course of infection with HHV-6 and HHV-7. In children who experienced HHV-6 infection first, followed by HHV-7 infection, the IgM response at the first HHV-6 infection was directed only against HHV-6, while no IgM response was directed against HHV-7 at the second HHV-7 infection. In contrast, in children who experienced HHV-7 infection first, followed by HHV-6 infection, the IgM response at the first HHV-7 infection was directed not only against HHV-7 but also against HHV-6. These data suggest that cross-reactive responses to heterologous viruses should be taken into consideration when making a diagnosis based on IgM antibody.

* Corresponding author. Mailing address: Department of Virology, Okayama University Graduate School of Medicine and Dentistry, 2-5-1 Shikatacho, Okayama 700-8558, Japan. Phone: 81-86-235-7167. Fax: 81-86-235-7169. E-mail: mariko{at}md.okayama-u.ac.jp.

Clinical and Diagnostic Laboratory Immunology, March 2002, p. 394-402, Vol. 9, No. 2
1071-412X/02/$04.00+0     DOI: 10.1128/CDLI.9.2.394-402.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.





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