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Clinical and Diagnostic Laboratory Immunology, March 2002, p. 491-492, Vol. 9, No. 2
1071-412X/02/$04.00+0     DOI: 10.1128/CDLI.9.2.491-492.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Effect of Exogenous Interleukin-18 (IL-18) and IL-12 in the Course of Brucella abortus 2308 Infection in Mice

Paolo Pasquali,1* Rosanna Adone,1 Louis C. Gasbarre,2 Claudia Pistoia,1 and Franco Ciuchini1

Laboratory of Veterinary Medicine, Istituto Superiore di Sanità, 00161 Rome, Italy,1 Immunology and Disease Resistance Laboratory, Animal and Natural Resources Institute, Agricultural Research Service, United States Department of Agriculture, Beltsville, Maryland 207052

Received 13 August 2001/ Returned for modification 6 November 2001/ Accepted 28 November 2001

In this study we demonstrated that combined inoculation of interleukin-12 (IL-12) and IL-18 reduced the number of bacteria in the spleens of mice infected with Brucella abortus 2308 and that the effect of the treatment was mediated by an increased capability of spleen cells to produce gamma interferon at the early phase of infection.

* Corresponding author. Mailing address: Laboratory of Veterinary Medicine, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Rome, Italy. Phone: 39-0-6-49902728. Fax: 39-0-6-49387077. E-mail: pasquali{at}iss.it.

Clinical and Diagnostic Laboratory Immunology, March 2002, p. 491-492, Vol. 9, No. 2
1071-412X/02/$04.00+0     DOI: 10.1128/CDLI.9.2.491-492.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Fernandez-Lago, L., Orduna, A., Vizcaino, N. (2005). Reduced interleukin-18 secretion in Brucella abortus 2308-infected murine peritoneal macrophages and in spleen cells obtained from B. abortus 2308-infected mice. J Med Microbiol 54: 527-531 [Abstract] [Full Text]  
  • Pasquali, P., Rosanna, A., Pistoia, C., Petrucci, P., Ciuchini, F. (2003). Brucella abortus RB51 Induces Protection in Mice Orally Infected with the Virulent Strain B. abortus 2308. Infect. Immun. 71: 2326-2330 [Abstract] [Full Text]  
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