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Clinical and Diagnostic Laboratory Immunology, July 2002, p. 921-924, Vol. 9, No. 4
1071-412X/02/$04.00+0     DOI: 10.1128/CDLI.9.4.921-924.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Complement-Mediated Neutralization of Canine Distemper Virus In Vitro: Cross-Reaction between Vaccine Onderstepoort and Field KDK-1 Strains with Different Hemagglutinin Gene Characteristics

Masami Mochizuki,1* Megumi Motoyoshi,2 Ken Maeda,2 and Kazunari Kai2

Laboratory of Clinical Microbiology, Kyoritsu Seiyaku Corporation, 1-12-4 Kudankita, Chiyoda-ku, Tokyo 102-0073,1 Department of Veterinary Microbiology, Faculty of Agriculture, Yamaguchi University, 1677-1 Yoshida, Yamaguchi 753-8515, Japan2

Received 13 December 2001/ Returned for modification 1 April 2002/ Accepted 22 April 2002

The properties of neutralization of antigens of canine distemper virus Onderstepoort and a recent field isolate, KDK-1, were investigated with strain-specific dog sera. A conventional neutralization assay indicated antigenic dissimilarity between the strains; however, when guinea pig complement was included in the reaction mixture, the strains were neutralized with not only the homologous but also the heterologous antibodies.

* Corresponding author. Mailing address: Laboratory of Clinical Microbiology, Kyoritsu Seiyaku Corporation, 1-12-4 Kudankita, Chiyoda-ku, Tokyo 102-0073, Japan. Phone: 81-3-3264-7117. Fax: 81-3-3264-6094. E-mail: msmmchzk{at}mb.infoweb.ne.jp.

Clinical and Diagnostic Laboratory Immunology, July 2002, p. 921-924, Vol. 9, No. 4
1071-412X/02/$04.00+0     DOI: 10.1128/CDLI.9.4.921-924.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.





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