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Clinical and Diagnostic Laboratory Immunology, July 2002, p. 933-934, Vol. 9, No. 4
1071-412X/02/$04.00+0     DOI: 10.1128/CDLI.9.4.933-934.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Influence of Antimalarial Treatment on Acquisition of Immunity in Plasmodium berghei NK65 Malaria

Ton That Ai Long, Shusuke Nakazawa, Maria Cecilia Huaman, and Hiroji Kanbara*

Department of Protozoology, Institute of Tropical Medicine, Nagasaki University, Nagasaki 852-8523, Japan

Received 10 December 2001/ Returned for modification 2 March 2002/ Accepted 2 April 2002

Antimalarial treatments during primary Plasmodium berghei NK65 infection in BALB/c mice influenced the acquisition of protective immunity against reinfection. Among subcurative treatments, lower doses better enable mice to acquire protective immunity than do higher doses. Eradication of parasites from the start of infection did not promote protective immunity.

* Corresponding author. Mailing address: Department of Protozoology, Institute of Tropical Medicine, Nagasaki University, 1-12-4 Sakamoto, 852-8523 Nagasaki, Japan. Phone: (81) 95 849-7838. Fax: (81) 95 849-7805. E-mail: f0512{at}cc.nagasaki-u.ac.jp.

Clinical and Diagnostic Laboratory Immunology, July 2002, p. 933-934, Vol. 9, No. 4
1071-412X/02/$04.00+0     DOI: 10.1128/CDLI.9.4.933-934.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.





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