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Clinical and Diagnostic Laboratory Immunology, September 2002, p. 1126-1128, Vol. 9, No. 5
1071-412X/02/$04.00+0     DOI: 10.1128/CDLI.9.5.1126-1128.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Helicobacter pylori-Specific Immune Responses of Children: Implications for Future Vaccination Strategy

Günter Bode,1 Isolde Piechotowski,2 Dietrich Rothenbacher,1,3* and Hermann Brenner1,3

Department of Epidemiology, University of Ulm, Ulm,1 Baden-Württemberg State Health Office, Stuttgart,2 Department of Epidemiology, German Centre for Research on Ageing, University of Heidelberg, Heidelberg, Germany3

Received 17 December 2001/ Returned for modification 21 March 2002/ Accepted 17 May 2002

We analyzed the specific anti-Helicobacter pylori immunoglobulin G (IgG) antibody profile for a sample of 824 asymptomatic schoolchildren in southern Germany (mean age, 10.7 ± 0.65 years) with an H. pylori-specific IgG enzyme-linked immunosorbent assay and Western blot analysis. The prevalence of infection was 19.8% (95% confidence interval, 17.1 to 22.7%). The immunoresponses were characterized predominantly by antibodies against low-molecular-mass antigens of 14 and 29 kDa, with a significant difference between children of German and Turkish nationalities (P = 0.0012 and P < 0.0001, respectively).

* Corresponding author. Mailing address: Department of Epidemiology, German Centre for Research on Ageing, University of Heidelberg, Bergheimer Str. 20, D-69115 Heidelberg, Germany. Phone: 0049 6221 548146. Fax: 0049 6221 548142. E-mail: rothenbacher{at}dzfa.uni-heidelberg.de.

Clinical and Diagnostic Laboratory Immunology, September 2002, p. 1126-1128, Vol. 9, No. 5
1071-412X/02/$04.00+0     DOI: 10.1128/CDLI.9.5.1126-1128.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.





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