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Clinical and Diagnostic Laboratory Immunology, September 2002, p. 1129-1131, Vol. 9, No. 5
1071-412X/02/$04.00+0     DOI: 10.1128/CDLI.9.5.1129-1131.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

CD4+ CD25+ T-Cell Production in Healthy Humans and in Patients with Thymic Hypoplasia

Kathleen E. Sullivan,1* Donna McDonald-McGinn,2 and Elaine H. Zackai2

Division of Immunologic and Infectious Diseases,1 Division of Clinical Genetics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 191042

Received 8 March 2002/ Returned for modification 23 May 2002/ Accepted 7 June 2002

Regulatory T cells are found primarily in the CD4+ CD25+ fraction of T cells and play an important role in the prevention of autoimmunity. We examined CD4+ CD25+ T cells in 33 healthy children and adults and compared them to a population with an inherited form of thymic hypoplasia and a predisposition to autoimmune disease. Absolute numbers of CD4+ CD25+ T cells were markedly higher in healthy infants than in infants with chromosome 22q11.2 deletion syndrome.

* Corresponding author. Mailing address: Division of Immunologic and Infectious Diseases, Children's Hospital of Philadelphia, 34th St. and Civic Ctr. Blvd., Philadelphia, PA 19104. Phone: (215) 590-1697. Fax: (215) 590-3044. E-mail: sullivak{at}mail.med.upenn.edu.

Clinical and Diagnostic Laboratory Immunology, September 2002, p. 1129-1131, Vol. 9, No. 5
1071-412X/02/$04.00+0     DOI: 10.1128/CDLI.9.5.1129-1131.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Bluestone, J. A., Tang, Q. (2004). Therapeutic vaccination using CD4+CD25+ antigen-specific regulatory T cells. Proc. Natl. Acad. Sci. USA 101: 14622-14626 [Abstract] [Full Text]  
  • Kasow, K. A., Chen, X., Knowles, J., Wichlan, D., Handgretinger, R., Riberdy, J. M. (2004). Human CD4+CD25+ Regulatory T Cells Share Equally Complex and Comparable Repertoires with CD4+CD25- Counterparts. J. Immunol. 172: 6123-6128 [Abstract] [Full Text]  


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