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Clinical and Diagnostic Laboratory Immunology, November 2002, p. 1396-1397, Vol. 9, No. 6
1071-412X/02/$04.00+0     DOI: 10.1128/CDLI.9.6.1396-1397.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Dichotomal Effect of the Coumadin Derivative Warfarin on Inflammatory Signal Transduction

Arnon P. Kater, Maikel P. Peppelenbosch,* Dees P. M. Brandjes, and Mika Lumbantobing

Laboratory for Experimental Internal Medicine, Academic Medical Centre, 1105 AZ Amsterdam, The Netherlands

Received 13 March 2002/ Returned for modification 30 May 2002/ Accepted 2 August 2002

Warfarin, a widely prescribed drug for preventing thrombosis, is thought to act solely through inhibition of vitamin K-dependent coagulation factors. Low concentrations of warfarin inhibit interleukin-6 production and phosphorylation of I-{kappa}B but not activation of p38 mitogen-activated protein kinase. Thus, warfarin inhibits inflammatory signal transduction, and this may contribute to clinical effects of warfarin.

* Corresponding author. Mailing address: Laboratory for Experimental Internal Medicine, G2-130, Academic Medical Centre, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands. Phone: (31)-20-5665910. Fax: (31)-20-6977192. E-mail: M.P.Peppelenbosch{at}amc.uva.nl.

Clinical and Diagnostic Laboratory Immunology, November 2002, p. 1396-1397, Vol. 9, No. 6
1071-412X/02/$04.00+0     DOI: 10.1128/CDLI.9.6.1396-1397.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.





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