CVI Accepts, published online ahead of print on 25 April 2007

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Clin. Vaccine Immunol. doi:10.1128/CVI.00082-07
Copyright (c) 2007, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved.

Immunization with PspA Incorporated into a Poly(Ethylene Oxide) Matrix Elicits Protective Immunity against Streptococcus pneumoniae

Quincy C. Moore III, LaShundra Johnson, Michael Repka, and Larry S. McDaniel^*

Departments of Microbiology, Surgery, and Medicine, University of Mississippi Medical Center, Jackson, MS 39216, and Department of Pharmaceutics, The University of Mississippi, University, MS 38677

^* To whom correspondence should be addressed. Email: LmcDaniel{at}microbio.umsmed.edu.

CBA/N mice were immunized with PspA in a poly(ethylene oxide) matrix to examine it's ability to deliver the antigen and modulate the immune response. All mice receiving PspA in the matrix survived a lethal pneumococcal challenge and had serum anti-PspA antibody levels statistically higher than mice receiving PspA alone (p<0.009).