CVI Accepts, published online ahead of print on 25 April 2007
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Clin. Vaccine Immunol. doi:10.1128/CVI.00093-07
Copyright (c) 2007, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved.

Extended Culture Enhances Sensitivity of Interferon-{gamma} Assay for Latent Mycobacterium tuberculosis infection

Ana Cehovin*, Jacqueline M Cliff, Philip C Hill, Roger H Brookes, and Hazel M Dockrell

Department of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, London, U.K.; Medical Research Centre, The Fajara, Banjul, Gambia

* To whom correspondence should be addressed. Email: a.cehovin{at}ucl.ac.uk.


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Abstract

To test the hypothesis that prolonged culture would enhance the sensitivity of latent tuberculosis detection by an interferon-{gamma} release assay, blood samples from 33 household contacts of Gambian tuberculosis patients were stimulated with M. tuberculosis-specific antigens. After 24 hours culture 66% were positive compared to 93% after 6 days.




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