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Clin. Vaccine Immunol. doi:10.1128/CVI.00477-07
Copyright (c) 2008, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved.

Mice with pulmonary tuberculosis treated with Mycobacterium vaccae develop strikingly enhanced recall IFN- responses to M. vaccae cell-wall skeleton

Departament de Genètica i de Microbiologia, Facultat de Biociències, Universitat Autònoma de Barcelona, 08193, Bellaterra, Catalonia, Spain; Servei d'Al·lèrgia, Hospital Universitari de Bellvitge, 08907, L'Hospitalet de Llobregat, Catalonia, Spain; Unitat de Tuberculosi Experimental, Fundació Institut per a la Investigació en Ciències de la Salut Germans Trias i Pujol, 08916, Badalona, Catalonia, Spain

^* To whom correspondence should be addressed. Email: esther.julian{at}uab.es.

	Abstract

Whole heat-killed Mycobacterium vaccae is used as immunotherapeutic agent in tuberculosis (TB), but the compound/s which trigger/s its immunostimulatory ability are not known. Herein, we showed that among different sub-cellular fractions, the cell-wall-skeleton induced a prominent expression of IFN- in splenocytes from both non-TB- and TB-M. vaccae-treated mice.